الفهرس 
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Abstract
This thesis includes three chapters, the first of which is a review on the glycosidase inhibitors and their chemotherapeutic value. The second chapter deals with the experimental part of the work. The third chapter is a discussion of the work carried out by the candidate. This chapter contains two parts; the first of which deals with the synthesis of some glycosidase inhibitors, and the second part deals with the inhibition studies of the glucosidase enzyme by methyl 6-deoxy-6-morpholino-a-D-glucopyranoside.
Reaction of methyl a-D-glucopyranoside (I) with p-toluenesulfonyl chloride in pyridine gave methyl 6-O-(p-tolysufonyl)-a-D-glucopyranoside (II). Nucleophilic dis-placement of the 6-tosyloxy group of II by morpholine afforded the corresponding methyl 6-deoxy-6-morpholino-a-D-glucopyranoide (III). The reaction of I with p-toluen-esulfonyl chloride, followed by acetylation with acetic anhydride in pyridine gave methyl 2,3,4-tri-O-acetyl-6-0-(p-tolysulfonyl)-a-D-glucopyranoside(IV). Treatment of IV with sodium iodide in methyl ethyl ketone (MEK) afforded the 6-deoxy-6-iodo derivative V whose reaction with morpholine in DMF followed by acetylation gave the tri-O-acetyl-6-deoxy-6-morpholino-a-D-glucopyranoside (VI) . The deacetylation of VI gave the target compound III.