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Abstract Results: Thirty adult patients suffering from rheumatoid arthritis (RA) were included in this study.Their ages ranged between 27 and 63 years old with a mean of 44.7±10.2 years. They were twenty-two female patients with age ranged between 27 and 63 years old with a mean of 41.7±9.8 years. and eight male patients with age ranged between 28 and 62 years old with a mean of 56.6±4.2 years. Modified HAQ was ranged between zero and 2.5 with a mean of 0.8 ±0.549. Disease activity of RA patients was examined according to both Mallya and Mace index ( Mallya and Mace, 1981) and also Simplified Disease Activity Index (SDAI) ( Smolen et al., 2003) and were found to have mostly from mild to moderate disease activity. Physical activity score was ranged from 0 with a maximum of 2. Triceps skin fold thickness (TSF) ranged between 8mm and 39mm with a mean of 21.7 ±8.3. Body mass index (BMI) ranged between 20.3 and 43.2 with a mean of 27.97 ±5.4. Regarding to their percentage of body fat , it ranged between 17% and 48% with a mean of 31.66 ±7.2. 14 IGF-1 was ranged between 60 and 376 ng/ml with a mean of 165 ±84.5 ng/ml. All the patients and healthy controls were matched according to their sex and age. Patients showed a low level physical activity and exercise with (p <0.001), a high % body fat (p = 0.009) and lower levels of IGF-1 with (p =0.04) in both patient’s groups when compared to the control group . % of body fat was highest in non –RA group with a mean of 37.2±8.1%, followed by the control group with a mean of 32.28±6.7% and was lowest in RA group with a mean of 31.6±7.2%. Also, IGF-I was highest in control group with a mean of 213±53 ng/ml, followed by the non –RA group with a mean of 201±75 ng/ml and was lowest in RA group with a mean of 165±84 ng/ml. The lowest physical activity score was in non –RA group ,then the RA group and higher scores in the control group. In comparisons done between one group versus each of the two groups; When The RA group was compared to both the non RA group and the control group in relation to IGF-1 it showed a significant values with (P=0.04) and ( P=0.03) respectively. Physical activity score was of significant value inbetween all groups with ( P < 0.01) .Percentage of body fat was of significant value (P=0.004) between the RA group and Non RA group but no significant values were detected between the RA group and the control group (P= 0. 8). Also no significant relations were detected when assessing disease activity in rheumatoid arthritis using multivariate Mallya and Mace disease activity index or Simplified disease activity index (SDAI) in relation to IGF-I. 15 When correlation was done between detailed physical activity score as being assessed by Physical activity scale score (Jackson and Ross,1992), a significant positive value was detected with IGFI ( P= 0.04) in our RA patients |