الفهرس 
Acute leukemiaOnly 14 pages are availabe for public view
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Abstract
Leukemia is defined as the uncontrolled proliferation or expansion of haematopoietic cells that do not retain the capacity to differentiate normally to mature blood cells. In addition, this abnormal blood cell development may result in a breakdown of cell-to-stroma interactions leading to the subsequent egress of immature blood elements from the bone marrow to the peripheral blood (PB). Therefore, leukemia can serve as a paradigm for metastasis in general. Matrix metalloproteinases are a family of zinc- and calcium dependent proteolytic enzymes capable of degrading most extracellular matrix (ECM) component. MMP9, known as gelatinase B or 92 KDa type IV collagenase, is one of the MMPs. MMP9 is able to cleave the type IV, V, VII, X and XIV collagens, it also has activity against aggrecan, fibronectin, osteonectin, plasminogen, MBP, IL-lbeta and elastin. Mature leukocytes, such as neutrophil,, granulocytes, monocytes, macrophage, and T lymphocytes are potent producers of MMP9. Normal and certain malignant B-cell types can also produce MMP-9.