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Abstract
Erectile dysfunction (ED) commonly results from endothelial
dysfunction of the penile vasculature. Stem cell-based therapies
targeting the penile endothelium have been gaining momentum in
preclinical studies. This work aimed to investigate the administration
of mesenchymal stem cells (MSCs) in the cavernous tissues of aged
rats (n=144). They were subjected to intracavernous injection of 1.5,
3.0 million MSCs and followed for 3 & 4 weeks (short term) and
another groups were injected by 0.5, 1.0 million MSCs followed for 4
& 5 months (long term). Dissected cavernous tissues were assessed for
cGMP, HO enzyme activity, NOS activity, RT-PCR of HO-1,
intracavernous pressure (ICP) and histopathology. In short term study,
cavernous cGMP, HO and NOS enzyme activities and ICP were
significantly increased in rats that received 1.5 million MSCs than 3.0
million doses compared with controls. In long term study, there was
also a significant increase of these parameters in rats that received 1
million MSCs more than 0.5 million doses compared with controls