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Abstract The current study was carried out on haemopoietic organs of sixty specimens of fish species of catfish as an example of fresh water fish and mugil fish as an example of salt water fish including liver, spleen and head kidney. The specimens of catfish were collected from Abbasa fish farm at Sharkia governorate while the specimens of mugil fish were collected from World Fish Center farm at Damietta governorate. The specimens were fixed in 100/0 buffered neutral formalin and Bouin’s fluid and subjected to processing till paraffin sections were obtained & stained histologically and histochemically. The anatomical findings revealed that, the liver of catfish was dark red in color while it was yellow in mugil and comprised the cranial wider part of the abdominal cavity back to pectoral fin. The spleen of catfish was dark red and rounded in shape situated behind the stomach while the mugil’s spleen was dark red and banana shaped or elongated and involved between coils of intestine. The head kidney of catfish and mugil fish comprised the pharyngeal region and was composed of bilateral lobes located anterior to the swim bladder and ventrolateral to the spinal column. The trunk kidney was extended into the trunk region. The histological findings exhibited that, the liver of catfish was covered by thin fibrous connective tissue capsule formed |