الفهرس 
Liver cirrhosisOnly 14 pages are availabe for public view
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Abstract
Portal vein thrombosis (PVT) is considered a rare event in the course of liver cirrhosis and it is mostly associated with hepatocellular carcinoma. The incidence of non-neoplastic PVT in cirrhotic patients is unknown so far, while its prevalence ranges from 0.6 to 15.8%.The expected pathophysiologic consequences of PVT are a further increase in the portal hypertension and a worsening of the liver function due to the decreased portal flow. Moreover, PVT could be considered a contraindication to liver transplantation in cirrhosi s.Clinical presentation of non-neoplastic portal vein thrombosis in cirrhotic patients has not been specifically studied and risk factors of PVT in this group of patients are still poorly understood.Recently, the pathogenesis of portal vein thrombosis in cirrhotic patients could be related to concomitant local acquired and inherited thrombophilic factors.It is suggested that, hyperhomocysteinemia resulting from genetic and/or nutritional disturbances in homocysteine metabolism is considered as an independent risk factor not only for atherosclerosis but also for venous thromboembolism. However, it is still unclear if elevated homocysteine levels can cause PVT in cirrhotic patients or not .