الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
 |  | from | 273 |  |  |
| | | from | 273 | | |
Abstract
Various disease conditions such as malignancy, diabetes mellitus, malnutrition and tions can produce structural and biochemical changes in the liver capable of Bring the rate of hepatic drug metabolism. The present study showed that the atic content of cytochrpme P-450 was markedly increased after 20 and 30 days of tion. The hepatic content of cytochrome P-450 began to decrease after worm iration, which started 35-40 days postinfection, and this content was markedly jased at 45, 60, and 75 days postinfection. In addition, the induction and tion of the content of cytochrome P-450 recovered after treatment of the infected its with praziquantel for three consecutive days before decapitation at each jual time point. It seems from this study that praziquantel may prevent the action i toxic metabolites of S- mansoni worms by inducing the synthesis of the reduced iglutathione which forms a complex with these metabolites since praziquantel is a inducer of the reduced form of glutathione. However, treatment of control Js with praziquantel, for the same period and the same dose, did not show any ton the hepatic content of cytochrome P-450. On the other hand, treatment of the rimental animals for one hour with different doses of N-methylnitrosourea and lylnitrosamine markedly induced the hepatic content of microsomal cytochrome
«
and this induction was directly proportional with increasing doses of both >unds, also after treatment of mice with diethylnitrosamine for one hour, the content of cytochrome P-450 was slightly increased at 10 and 20 mg/kg body t, while 40 mg/kg did not show any effect on this content. This observation 35 further evidence for the dependency of cytochrome P-450 modification and rmicrosomal enzymes on the chemical structure of the tested compounds.
data of our present study revealed the ability of £• mansoni infection, at 20 and s postinfection, to alter the arylhydrocarbon hydroxylase activity. However,