الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Various disease conditions such as malignancy, diabetes mallitus, malnutrition and infection can produce structural and biochemical changes in the liver that capable of altering the rate of hepatic drug metabolism. The hepatic microsomal cytochrome P-450 dependent monooxygenases play a role in the metabolism and disposition of an extremely wide range of exogenous as well as endogenous compounds.
Various xenobiotics, such as drugs, pesticides, food additives and environmental pollutants, have been reported to alter the activities of enzymes.
This study was planned to investigate the association of cancer induction and infections of bacteria and schistosoma with special emphasis on the environmental factors responsible for such association.
In order to achieve such a purpose in vivo experiments of single and mixed infections of mice by bacteria, schistosome and/or treated with nitrate were carried out. Analysis of nitrite as well as
:hydroxylamine in urine and blood samples was done. The total hepatic microsomal content of cytochrome