الفهرس 
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Abstract
Most of the drugs are metabolized by the monoxygenases of the liver microsomes.Recently, it has become increasingly evident that the pharmacologic and toxicologic actions of drugs may be frequently changed by the alterations in the rate of drug metabolism.
The present study is concerned with the effect of some anti-inflammatory drugs on certain classes of enzymes, the microsmal N-demethylase, the microsomal arylhydrocarbon hydroxylase, in addition to the terminal oxidase, cytochrome P-450. Various drugs have been reported to alter the activities of the drug metabolizing enzymes of the liver. Our data showed that pyrazole increased the DMN-demethylase I activity, while phenylbutazone decreased the activity of this enzyme. However, a similar effect was obtained on DMN-demethylase II. Effect of indole pretreatment for six days on the activities of DMN-demethylases I & II was similar to the effect of phenylbutazone pretreatment for one day. However, the effect of indomethacin, an indole derivative, on the activity of both enzymes was opposite to the effect of indole. These results suggested that the substitution in the chemical structure of the drugs might alter their biological effect on drug metabolizing enzymes.