الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide and about 20% of the infected patients progress to liver fibrosis. It is responsible for significant morbidity and mortality worldwide.
For many years liver biopsy has been considered the gold standard for the evaluation of liver fibrosis staging. However, many patients may be reluctant to do it and it is subject to sampling errors and inter-observer variability. So, it was necessary to find non-invasive markers of liver fibrosis.
The aim of the present study was to assess the value of measurement of serum tumor markers CA 19-9 and CA 125 as predictors of severity of liver fibrosis in chronic hepatitis C patients. It was performed on 50 patients of variable ages and sexes with chronic hepatitis C referred to or admitted at the Gastroenterology and Hepatology Unit and those who recruited from the Hepatology Clinic, Department of Medicine, Ain Shams University Hospital starting from July 2006 to January 2008, including 31 males and 19 females, with ages ranging from 18 to 50 years (with a mean age = 36.18).
All the patients were submitted for detailed clinical history, a thorough clinical examination and routine laboratory investigations. Assay of serum carbohydrate antigen 19-9 (CA 19-9) and Serum cancer antigen 125 (CA 125) was done and all of them underwent liver biopsy after taking an informed written consent.