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Abstract
The present study is designed to investigate the protection conferred by dietary supplementation of turmeric (CL), Ginkgo biloba extract (EGb), silymarin (SL) separately or in combination in comparison to vitamin E (VE) against iron-induced oxidative stress. The prophylactic efficiencies of the studied natural agents have been assessed by monitoring the levels of lipid peroxides as thiobarbituric acid reactive substances (TBARS) in plasma and liver, reduced glutathione (GSH) level in blood and liver, as well as antioxidant enzymes activities such as superoxide dismutase (SOD), and catalase (CAT) in liver and blood. Also, the effect of these agents was studied on the activities of Epoxide hydrolase (EH) in liver cytosol and microsomes as well as glutathione S-transferase (GST). Results revealed that exposing the rats to iron overload 6 hrs before decapitation caused a significant rise in plasma and hepatic TBARS levels associated with blood lysate GSH depletion. Concomitantly, a significant rise in erythrocyte and liver cytosol SOD, hepatic CAT activity, and GST level was, also, noted in iron-overloaded group (FE) as compared to normal control (N) group. Both microsomal and cytosolic EH activities were significantly elevated by iron overload; however, blood lysate CAT and hepatic GSH levels were unchanged. Pretreatment with CL, EGb, SL, separately or in combination helped to ameliorate iron-induced biochemical changes in rats. Accordingly, the present work suggests that turmeric; silymarin, Ginkgo biloba might be useful herbal remedies to suppress oxidative damage caused by iron overload.