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Abstract
deeding oesophageal varices as a complication of
portal hypertension Is the most common cause of upper gastrointestinal hemorrhage in Copt It is the leading cause of death in patients with schistosmal hepatic fibrosis and portal hypertension. Although the initial bleeding episode may be fatal, patients usually have multiple episodes extending over many years.. The economic impact of this disease is compounded by the fact that it affects individuals at the peak of their productive life..
Portal hypertension is a common cilsical syndrothe associated with chronic liver disease and is characterized by a •.. pathological increase in portal pressure, Elevated.portal pressare result, in extensive formation of portosystemic collaterals that divert portal blood to the system, • circulation. This cause many haernodynamic .disturbances, which result in complications of •
portal hypertension. The major consequences of portal
:hypertension are gastrointestinal bleedirrg from niptured
•oesophageal varices, oodles formation. and • hepatic
eacephaiopathy. A grasp of the biological mechanisms in the• pathogenesis of portal hypertension is essential to an understanding of the complications of chronic liver disease and to the development of rational therapies..