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Abstract
The present study was carried out to elucidate the toxic effect
of the fungicide metalaxyl on blood picture, chromosomes of bone
marrow cells, nucleic acid content, biochemical parameters,
histopathological picture besides metalaxyl residues in rat tissues.
Eighty mature albino rats were divided into two main groups
each group contain fourty rats. The first group divided into
thiliy(30) rats administered orally lis LOso ofmetalaxyl (l33.8
mg/kb b.wt.) three times weekly for two weeks, the rest of rats ( 10)
served as control. The second group also divided into 2 sub groups,
a treated group contain thirty (30) rats administered 1/10 LOso of
metalaxyl (66.9 mglkb b.wt.) orally twice weekly for two months
and the other ten( 1 0) rats served as control.
Effect of metalaxyl on body weight:
In this study we noticed that there was a decrease in the final
weights of treated rats when compared to the initial weights, there
was also a significant decrease in the weight of treated rats of both
groups comparing with control groups. Rats administered lis LDsoof
metalaxyl (133.8 mglkb b.wt.) three times weekly for two weeks
showed a clear decrease in the liver weight comparing with control,
this decrease was also obvious in rats administered I I 10 LOso of
metalaxyl (66.9 mglkg b.wt.) orally twice weekly for two months
when compared to control at the end of the experiment. This
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experiment also revealed a significant decrease in kidney weight of
both treated groups in comparison to control groups. The spleen