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Abstract
2. sparing therapies include transuretheral resection (TUR) alone, neodymium YAG laser, radiotherapy alone, partial cystectomy, chemotherapy alone and chemotherapy plus radiation (concurrent, alternating and sequentialr . The nonbladder sparim treatments include radical surgery, chemotherapy plus surgery, radiation plus surgery and chemotherapy plus radiation and surgery...Ia.’.
A number of single chemotherapeutic agents with different mechanisms of action are active against urothelial carcinoma b. complete responses were rare.. However combination chemotherapeutic regimens have been introduced in the treatment of MIBC with promising results and fair toxicity...1.0. 5-fluorouracil (5-FU), alpha interferon 2b (a-2b IFN) and cis-platin (cis-diamminedichloroplatinum) (CDDP) are chemotherapeutic agents active against bladder emcee’’’.
Orsatti et al (1995) reported good results in the treatment of invasive bladder cancer using alternating chemotherapy (5-FU, CDDP) and radiotherapy with different schedules.. Chau. et al (1996) concluded that concurrent CDDP and rad.tion is a potentially curative and conservative treatment for patients with MIBC who are not candidates for radical surgery.. Logothetis et al (1992) tised a combination of (5-FU, CDDP, and alb IFN) (FAP) in metastatic urothelial carcinoma with 61% total response rate..
The optimal treatment for MIBC is not known.. Many therapeutic modalities have an effect on the tumour but there exists no course of treatment which can guarantee cure or long-tem survival and which can be adopted with a reasonable amount of certainity.”.620.