الفهرس | Only 14 pages are availabe for public view |
Abstract One hundred and eighty male albino rats were divided into 3 main groups, each divided into 4 subgroups, to study the toxic and pathological lesions of butylated hydroxyanisole, ethoxyquin and sodium metabisulfite. Rats of group 1 were divided into 4 subgroups. They received 0.5, 1, 2% BHA, respectively in the diet. The subgroup 4 was kept as control. Rats of group 2 were divided also into 4subgroups and received 40, 200, 400 mg/kg B~ ethoxyquin, respectively by gavage in corn oil and subgroup 4 was kept as control. Rats of group 3 were divided into 4 subgroups and received 4, 6, 8 % sodium metabisulfite, respectively in the diet with addition of 50mg/kg thiamine to prevent thiamine deficiency due to destruction of this vitamin by sulfite, and subgroup 4 was kept as control. Five rats from each subgroup were sacrificed 1, 3 and 6 months in case of group 1 while sacrificed 1, 2 and 3 months incase of group 2 and group 3 . The liver of rats received butylated hydroxyanisole (group 1), revealed variable lesions which differ according to the duration and doses. The lesions varied from congestion, lymphocytic infiltrations in the portal areas, hyperplasia of the bile ducts, cloudy swelling, vacuolar and hyDROPic degeneration of hepatocytes and progressed to multiple areas of coagulative necrosis at 6months in subgroup 3. The most striking lesions were detected in the stomach. They include congestion and round cell infiltration, mild hyperplasia of the . squamous cells of the forestomach which proceeded to marked papilloma especially at the area of the limiting ridge with severe acanthosis, hyperkeratosis and formation of papillary like projections in the submucosa. Hyperplastic effects were absent in the I glandular stomach. The intestine showed focal desquamation, and round |