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Abstract
One hundred and eighty male albino rats were divided into 3 main groups, each divided into 4 subgroups, to study the toxic and pathological
lesions of butylated hydroxyanisole, ethoxyquin and sodium metabisulfite.
Rats of group 1 were divided into 4 subgroups. They received 0.5, 1, 2%
BHA, respectively in the diet. The subgroup 4 was kept as control. Rats of
group 2 were divided also into 4subgroups and received 40, 200, 400
mg/kg B~ ethoxyquin, respectively by gavage in corn oil and subgroup 4
was kept as control. Rats of group 3 were divided into 4 subgroups and
received 4, 6, 8 % sodium metabisulfite, respectively in the diet with addition of 50mg/kg thiamine to prevent thiamine deficiency due to
destruction of this vitamin by sulfite, and subgroup 4 was kept as control.
Five rats from each subgroup were sacrificed 1, 3 and 6 months in case of
group 1 while sacrificed 1, 2 and 3 months incase of group 2 and group 3 .
The liver of rats received butylated hydroxyanisole (group 1),
revealed variable lesions which differ according to the duration and doses.
The lesions varied from congestion, lymphocytic infiltrations in the portal
areas, hyperplasia of the bile ducts, cloudy swelling, vacuolar and hyDROPic
degeneration of hepatocytes and progressed to multiple areas of
coagulative necrosis at 6months in subgroup 3. The most striking lesions
were detected in the stomach. They include congestion and round cell
infiltration, mild hyperplasia of the . squamous cells of the forestomach
which proceeded to marked papilloma especially at the area of the limiting
ridge with severe acanthosis, hyperkeratosis and formation of papillary like projections in the submucosa. Hyperplastic effects were absent in the I
glandular stomach. The intestine showed focal desquamation, and round