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Abstract
Bladder instability is a common condition, and the main aim of drug treatment is to give a symptomatic relief of frequency, urgency and urinary incontinence. This should be achieved by selectively depressing the unstable bladder contractions without influencing the normal micturation contraction.
The aim of the present study was to compare the effect of a calcium channel blocker (Nifedipine) and a potassium channel opener (Pinacidil) on acetyl chol ine induced contraction of isolated detrusor muscle of the rabbit’s urinary bladder.
A dose response curve to acetyl choline was obtained by various concentrations of acetyl choline till we reach the maximal response, then WG