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Abstract
Hepcidin, a circulating peptide hormone, is the master regulator of systemic iron homeostasis. In the present study, we aimed to assess levels of serum pro-hepcidin, the pro-hormone form of hepcidin, its relation with iron status, acute-phase reactants, and its possible role in the development of anemia in a cohort of RA patients as to date, there are no commercial kits available for the measurement of hepcidin in serum specimens. The study includes 30 patients with RA (24 females & 6 males) & 30 healthy controls(16 females & 14 males) & we conclude that pro-hepcidin levels correlate with disease activity as negative acute phase reactant but its’ levels analysis not correlate with anemia in RA group .