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Abstract
Rheumatoid arthritis (RA) is a highly heterogeneous disease with respect to its joint destructivity. Deficient apoptosis in rheumatoid synovial tissue has recently been demonstrated. Survivin is a 142-amino-acid protein that belongs to the IAP family, It can downregulate, directly or indirectly, both death-receptor-mediated and mitochondria mediated pathways of apoptosis. survivin was assessed by an ELISA in blood samples collected from 35 RA patients. Results were related to joint erosivity at the time of sampling. Survivin levels were significantly higher in patients with destructive disease as compared with in RA patients displaying a non-erosive disease.