الفهرس 
Cover Page Title in EnglishOnly 14 pages are availabe for public view
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Abstract
Environmental pollution by insecticides constitute great importance and hazard throughout tne world especially in the developing countries where there has been a steady increase in insecticides use without the corresponding development of a system of education of users in safe handling of these toxic compounds. Increasing utilization of oraanopnosphorus compounds COPs) as insecticides has created considerable concern over their toxic effects, especially at early developmental stages. Such concern depends substantially on the fact that these compounds are mainly liposoluble and of low molecular weight and thus are able to cross the placental barrier. Most investigations into the developmental toxicity of OPs conducted to date have examined teratogenicity. some aspects of behavior and changes in endocrine functions. Metabolic and pharmacokinetics studies of OPs indicating their presence in fetal tissues of various species including man have been long known. However there is little data regarding the effects of OPs exposure’during pregnancy on fetal and neonatal cholinesterase activity. The purposes of this work is to evaluate differences in the inhibition and recovery of maternal and fetal cholinesterase activity and its molecular forms following a single oral dose of chlorpyrifos. Also, the in vitro metabolic study presented here was to evaluate the role of the liver and extrahepatic tissues in mediating the acute toxicity of chlorpyrifos which is widely used insecticide for the control of agricultural pests ( cotton leafworm) and ectoparasites on cattle and sheep and also for the control of hse hold pest (cockroaches) -
Cholinesterase studies was carried out on groups of pregnants sprague—Dawley rats 13—15 day of gestation. Animals were ttdomly divided into control group treated orally with corn oil. and treatment groups received single oral dose of