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Abstract
Acute myeloid leukemia is a hematologic malignant disease
with increased proliferation of hematopietic cells in an abnormal
clonal fashion. AML accounts for 15 to 20 percent of the acute
leukemias in children and 80 percent of the acute leukemias in
adults.
Monosomy 7 is a numerical chromosomal abnormality in
which chromosomal material is lost. Monosomy 7 is one of the
most common chromosomal abnormalities found in the
leukemic cells of patients with acute myelogenous leukemia.
Because patients with monosomy 7 have a poor prognosis,
their identification is important for treatment planning.
The aim of the present study was to demonstrate the
percentage expression of numerical abnormalities of
chromosome 7 in Egyptian AML (M2) patients using
fluorescence in situ hybridization.
Ten patients with AML (M2) and 10 controls were included
in the study. They were subjected to complete hemogram bone
marrow aspiration and fluorescence in situ hybridization to
detect percentage of monosomy 7.
This study was carried out on non dividing inter phase cells.
All the included cells were malignant blast cells obtained from