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Abstract
the stydy aimes to Since the complex inunune mechanisms that mediate local
inflammatory reaction in inflammatory bowel disease (illD) are poorly
understood, it was so intended to study the role of VCAM-I in patients with
UC and to study also its relation with the severity of the disease.Forty individuals were included in this study to evaluate the role of
VCAM-I during activation of the course of Uc. The individuals were
classified into two groups:
Group I: comprised 30 patients with UC’ and with mean of age
40.4±IO.5 years ...
Group II: included 10 healthy individuals with mean age of
41.9±8.7 years and taken as control group
Patients of this study were diagnosed on basis of clinical, radiological,
endoscopic and histopathological findings -the selected patients were
subjected to:
I-Clinical examination with history taking
2-Stool analysis by simple sedimentation method
3-Complete CBC.
4-ESR.
5- C-reactive protein.
6- Colonoscopy and obtaining biopsy from presenting lesions for
histopathological examinations.
7- Measurement of VCAM-I in serum of patient during periods of
activation and remission.