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Abstract
Endothelin is a long lasting vasoconstrictor, it acts as a pressor
which has been confirmed in human subject. Recently it was found that
the intrarenal vasoconstrictors such as the leukotrienes and endothelins
are activated with the progression of the liver disease.
The renal vasoconstriction is counterbalanced by the intrarenal
hyperproduction of vasodilating prostaglandins and kallikreins. When this
balance is lost by any mechanism, the renal vascular resistances
dramatically increase and hepatorenaI syndrome develops.
The aim of this study is to find the plasma endothelin-I in plasma in
cases with chronic liver disease and to know whether it is involved in the
prognosis of renal dysfunction present in these conditions.
For this purpose (50) cases were grouped as follows:
o Group I (20) patients with compensated liver disease.
o Group II (20) patients with decompensated liver disease.
o (10) normal subjects as control.