الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
A total of 118 healthy rabbits weighing from 1 to 1.5 kg was used for this study. The rabbits were fed on a balanced ration free from antibiotics obtained from Atmida Company. The rabbits were classified into 5 groups. The first group (25 rabbits) was given a single oral dose of an aqueous flumequine solution at a dose level of 12 mg/kg B.wt. The second group (25 rabbits) was given flumequine orally at a dose level of 12 mg/kg B.wt. for five successive days. The third group (30 rabbits) was given a single oral dose of enrofloxacin solution at a dose level of 10 mg/kg B.wt. The fourth group (30 rabbits) was given enrofloxacin orally at a dose level of 10 mg/kg S.wt. for 5 successive days. The fifth group (10 rabbits) was used as a negative control. Blood samples were taken after different times of applications as well as three rabbits were slaughtered after different times of applications. The samples were assayed for determination of flumequine and enrofloxacin in serum as well as their residual contents in muscles and internal organs. The samples were assayed by using agar diffusion test. The obtained results revealed that:
1. Plumequine could be detected in serum of rabbits until 36 hours after a single oral administration with a maximum concentration of 3,3 ± 0.27 jag/ml which was obtained after 3 hours post administration.
2. Flumequine could be detected in serum of rabbits until 36 hours after the last dose of 5 successive oral administrations with a maximum mean concentration of 3.5 ± 0.58 ig/ml which was obtained after 3 hours post administrations.