الفهرس | Only 14 pages are availabe for public view |
Abstract The aims of the study are: 1- Evaluation of serum levels of SlCAM-I, Svcam-I and Selecting in type II diabetic patients with diabetic retinopathy and correlate their levels with other biochemical parameters. 2-evaluation of the role of s ICAM-I, s VCAM-I and selecting as one of the possible mechanisms of diabetic retinopathy. 3- Increased levels of circuiting forms of s VCAM-I, Slcam-I,sE-selectin are closely associated with the presence of vascular complications in diabetic patients and hence can be used as a circulating marker for the presence of such complications. 4- Microalbuminuria is a reliable marker of diabetic retinopathy and high level may serve as an indicator of proliferate diabetic retinopathy 5- Funds examination for diabetic patients at least annually. Conclusions: Good glycaemia control is very important factor in preventing or decreasing diabetes complications. Good control of lipids is very important factor in preventing or decreasing diabetes complications. Good control of lipids is very important factor in preventing or decreasing diabetes complications. Regular screening for microalbuminuria with appropriate medical management can reduce the risk of blindness. Measurements of s VCAM-I, Sicam-I selecting levels in diabetic patients may be clinically useful for assessing diabetic retinopathy and may serve as a marker of inflammation. Lt is hypothesized that serial s VCAM-I,Sicam-I selecting and microalbuminuria levels could be of benefit in identifying patients at high risk for the development of clinically apparent vascular complications (Schmidt et al.,1995).lt might provide surrogate maker for assessment of therapy designed to attenuate the progression of vascular disease and might become target molecules to fight vascular diabetic complications. |