الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
The aim of this work is to estimate plasma level of lipoperoxides (malondialdehyde) as it is a major by-product during lipid peroxidation influenced by oxygen cardial production and its relation to ferritin serum level and echocardiographic measurements in patients with Cooley’s anaemia.
In conclusion, our results confirm the peroxidative damage generated by iron overload in thalassemia patients, as evidenced by increased level of MDA in patients compared to controls, as it shows a very good positive correlation between serum ferritin and MDA, but cannot confirm iron peroxidative damage on thalassemic heart using echocardiography as there is no significant correlation between ferritin and MDA, and echocardiographic findings.
From our study we advise measurement of NTBI for follow up of thalassemic patients with ferritin serum levels.
Also, we advise more researches including MDA & NTBI, and their correlation with radionuclide angiography of thalassemic heart, because it is more sensitive than echocardiography and may reveals early and minor effect of iron peroxidative damage on the cardiac muscle.
Also, we advise the use of antioxidants to counteract the peroxidative effect of excess iron in thalassemic patients as L-carnitine, and advise more researches for use of other antioxidants (as vit. A & E, as there are trials for their intravenous administration in liposome’s to enhance organ targeting and distribution. Vitamin C should be carefully administrated, as it can have prooxidant activity in the presence of iron overload and deferoxamine.