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Abstract
In the nephrotic state, the protein loss generally exceeds 2gm / 24 hours and is composed primarily of albumin. In general oedema appears when the serum albumin level falls below 2 gm /dI (3)
In the minimal change disease, there is no evidence of structural damage to the basement membrane. The defect is in the electrostatic function of the glomemlar barrier to protein filteratioe). It is suggested that hormonal circulating factors (Lymphokines), released from T lymphocytes sensitized against gtomerular antigen is the cause of loss of glomerular polyanionie barrier (8.9.’)
The large majority of children with minimal change disease are steroid responsive. They will have repeated relapses until the disease resolves itself spontaneously towards the end of the second decade of life 1.12).
Approximately 50 — 60 % of patients with mesangial proliferation will respond to corticosteriod therapy, and approximately 20 % of patients with focal sclerosis respond to prednisone or cytotoxic drugs or bode).
Because of the potential severity of infection in nephrotic
ch
ildren, the problem of the selection of effective antibiotic therapy is of a vital imponance3). Most importantly a broa