الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Although the skin as a route for drug delivery can offer many advantages, including avoidance of first-pass metabolism, lower fluctuations in plasma drug levels, targeting of the active ingredient for a local effect and good patient compliance, the barrier nature of skin makes it difficult for most drugs to penetrate into and permeate through it. During the past decades there has been wide interest in exploring new techniques to increase drug absorption through skin.
Topical delivery of drugs by liposomal formulations has evoked a considerable interest. Despite intensive research, results on the interaction of liposomes with skin are contradictory. Recently, it became evident that classic liposomes are of little or no value as carriers for transdermal drug delivery as they do not deeply penetrate skin, but rather remain confined to upper layers of the stratum corneum. A new type of lipid vesicles (Transfersomes®) called deformable liposomes was recently reported to penetrate intact skin carrying therapeutic concentrations of drugs, but only when applied under non-occluded conditions. Several studies have reported that deformable liposomes were able to improve in-vitro skin delivery of various drugs and to penetrate intact skin invivo, transferring therapeutic amounts of drugs with efficiency comparable with subcutaneous administration. Ethosome is another novel lipid carrier showing enhanced skin delivery.
The objectives of the current thesis were to formulate, characterize and evaluate some vesicular systems as carriers for skin delivery of drugs.
Part One: Deformable liposomes and etbosomes for skin delivery of ketotifen
Chapter One: Deformable liposomes and ethosomes of ketotifen: preparation, characterization and in-vitro evaluation
This chapter dealt with investigation of deformable liposomes and ethosomes as carriers for skin delivery of ketotifen fiimarate (KT). The study included preparation, characterization, stability testing and in-vitro evaluation of the formulations, using rabbit pinna skin.