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Abstract
Experimentally S. haematobium infected hamsters were compared with uninfected ones. Telomerase activity increased significantly in the infected liver and urinary bladder at 120 up to 240 DPI. TNF- was increased only at 240 DPI. Histopathological lesions in the infected liver was predominantly caused by the eggs that were laid in the portal venous system, and become trapped in hepatic sinusoids and sequestered within granulomatous lesion. The fibrosis associated with granuloma formation seen clearly at 240 DPI. In the urinary bladder the granuloma were found in the submucosal layer and the transitional epithelia of the mucosa infiltrated with blood cells and become thicker by time. S. haematobium infection affect protein synthesis and protein profile in the serum, liver, urinary bladder and urine of the infected hamsters.