الفهرس | Only 14 pages are availabe for public view |
Abstract In this work, we aimed to synthesize some new heterocyclic compounds from oxazolone series hopping that, the new compounds will have certain biological effects or other applied uses. The thesis is divided into three chapters. Chapter I:This chapter includes the literature survey on the synthesis of 4-arylmethylene-2-phenyl-2-oxazoin-5-one derivatives and their reactions. Chapter II: This chapter is concerned with the discussion of the experimental results obtained in this work. We used 4-arylmethylene-2-phenyl-2-oxazolin-5-one derivatives (Ia-c) as starting materials and their reactions with p-nitrophenylazo aniline derivatives (IIa-c) were described. We found that, the reaction produces depends on the reaction conditions. Thus, when 4-arylmethylene-2-phenyl-2-oxazolin-5-one (Ia-c) refluxed with p-nitrophenylazo aniline derivatives (IIa-c) in ethanol we obtained the corresponding carboxamide derivatives (IIIa-i), while when the reactions were carried out under fusion condition and in the presence of freshly fused sodium acetate, we obtained the corresponding imidazolinone derivatives (IVa-i) [scheme 1]. 2-Phenyl-4-phthalidyliden-1,3-oxazolin-5-one (V) was used as oxazolone derivative and its reaction with p-nitrophenylazo aniline derivatives (IIa,c) were studied that gave the corresponding 2-[2-alkyl-4-(4-nitrophenylazo)-phenyl]-isoindole-1,3-diones (Via,b) respectively [scheme 1] <Treating of 4-chlorophenyl methylene-2-phenyl-2-oxazolin-5-one (Ic) with hydrazine gave the corresponding 1-amino-4-(4-chlorobenzylidene)-2-phenyl-imidazolin-5-one (VIIb). The later when fused with arylmethylene-2-phenyl-2-oxazolin-5-one (Ib,c) the corresponding (4-(4-chlorobenzylidene)-4`-(4-arylidene)-2,2`-diphenyl-4H,4`H-[1,1`] biimidazolyl-5,5`-diones (VIIIa,b) were obtained [scheme 2]. |