الفهرس 
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Abstract
It is known that several pyrazoles and their derivatives possess different pharmacological activities especially their applications as antiinflammatory, analgesic and antimicrobial agents. The present thesis deals with the synthesis of some pyrazole derivatives and testing their acti vities towards some bacteria.4-Arylidene-3-methyl-l-phenyl-2-pyrazolin-5-ones (I a-c) reacted with some active methylene compounds such as malononitrile, ethyl cyanoacetate, ethyl acetoacetate, cyano acetamide and 3-methyl-l- phenyl-2-pyrazolin-5-one under Michael reaction conditions to give the Michael adducts which cyclized to the corresponding pyrano[2,3-c] pyrazole derivatives (2a-c), (4a-c).(5a-c), (6c) and (7a-c) respectively.The pyranopyrazole derivatives (2a-c) could be used for the synthesis of other derivatives. Alkylation of ( 2a-c ) with ethyl chloroformate gave the corresponding 4-aryl -5-cyaoo-6-( N,N- dicarboxyethyl ) amino -1,4- dihydro -3- methyl-l-phenyl pyrano[2,3-c] pyrazole derivativestxa-c). The ester derivatives (8a-c) were reacted with hydrazine hydrate yielding the starting materials (2a-c) instead of the expected hydrazides (9a-c).Reactions of (2a-c) with triethyl orthoformate affording ethyl-N ( 4-al’yl -5- cyano -1,4- dihydro -3- methyl-I- phenyl pyrano [2,3-c] pyarzole-e-yl ) methanimidate derivatives (lOa and b). The latter