الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
It is well-documented that phthalazines, either attatched or fused to other heterocycles possess a broad spectrum of biological activities especially antthypertensive, anticancer and antimicrobial activities.
Based on the above-mentioned information, various series of compounds were synthesized in this thesis containing different heterocyclic moieties joined or fused to phthalazine nucleus to be screened for their antihypertensive, anticancer and antimicrobial activities. The present thesis
comprises the following chapters.
Introduction:
It constitutes a concised survey on the recent researches on biologically active phthalazines as antihypertensive, anticancer, antimicrobial, antiviral, antiinflammatory,. analgesic, antidiabetic, antihistaminic, anticonvulsant agents and many others.
Research objectives:
It deals with the rationale upon which the synthesized compounds have been designed.
Discussion:
) This chapter includes a discussion of the theoretical basic concepts for the afready reported acceptable methods for the synthesis of the designed compounds, referring to the available knowledge in the literature.
j This necessitated to include a survey of the reported methods utilized for the preparation of compounds of comparable structures. This chapter is subdivided into three parts:
Part I: It describes preparation of the key intermediate 4-hydrazino- l(2H)-phthalazinone which was then subjected to cyclization using specified reagents giving rise to the corresponding triazolo[3,4-a]- phthalazinone, pyrazol-l -ylphthalazinone and tnazino[3 ,4-a]phthalazinone.