الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
 |  | from | 240 |  |  |
| | | from | 240 | | |
Abstract
Recently, considerable attention has been focused on the use of ,jioadhesion for drug delivery purposes. There has been a growing interest in bioadhesive polymers as controlled-release systems for both local and systemic drugs. Buccal mucoadhesive devices represent a feasible and accessible way, which permits prolonged retention of drugs to the absorbing membrane, thus, reaching systemic circulation in a reproducible concentration. One added advantage is the avoidance of first pass effect associated with peroral route. Regarding local delivery, mucoadhesive devices ensure therapeutic drug level over prolonged period in the oral
The main objectives of the thesis are the development and evaluation of mucoadhesive buccal dosage forms for the local and systemic drug delivery.
PART I of the thesis focused on the design of buccal mucoadhesive tablets intended for systemic effect. Water-soluble drugs, diltiazem hydrochloride (DZ) and metoclopramide hydrochloride (MP), both suffering from extensive first pass effect, were chosen.