الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
Part I of this thesis involved the development of floating
modified release formulations. In chapter I, a system for ketoprofen
designed to increase its residence time in the stomach, without contact with the mucosa, was achieved through the preparation of
floating microballoons by the emulsion-solvent diffusion technique
with some modifications.
Preliminary trials to select the best conditions for the. preparation of microballoons with wall consisting of Eudragit polymer, involved studies on the effect of type of surfactant, volume of oil to water phase, type and speed of agitation. SLS (0.2%) in 400 ml water as aqueous phase and 3 ml organic phase consisting of dichioromethane and ethanol (1:1), were chosen for production of microballoons with best characteristics as evidenced by microphotographs. The drug was loaded within the microbahloon wall in a ratio of 1:1 with the polymer. Four different ratios of
Eudragit S 100 (ES 100) with Eudragit RL (ERL) were used to form
the microballoons, namely: 1.5:0.5 (Fl), 0.5:1.5 (FIl), 1:1 (Fill)
and 2:0 (FIV) ES:ERL respectively. The microballoons were filled into hard gelatin capsules. A commercial sustained release formulation in capsule form, was also included in the study.