الفهرس 
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Abstract
Aim of the work
1- Measuring of microalbuminuria and fibronectin for early detection of diabetic nephropathy in order to slow down of nephropathy and delay end stage renal disease.
2- Statistical correlation between both parameters and with other routine investigation according to duration of and its type.
3- Comparison between different groups in each parameter with the control group.
Summary and conclusion
This study was done on diabetic patients as a trial to assess the role of microalbuminuria and fibronectin in the early detection of diabetic nephropathy. HA1c was used as a marker of control of diabetes.
In the current study, 75 individuals were divided as follows:
Group I included 15 apparently healthy individuals as the control group.
Group IIa included 15 patients with IDDM <5 years duration.
Group IIb included 15 patients with IDDM >10 years duration.
Group IIIa included 15 patients with NIDDM <5 years duration.
Group IIIb included 15 patients with NIDDM >10 years duration.
The mean value of microalbuminuria and fibronectin were significantly higher in groups (IIb and IIIb) when compared with either the control group or the other two corresponding groups (IIa and IIb).
As regards HbA1c there was significant increase in all patients groups when compared to the control group. But no significant difference was found on comparing the corresponding groups.
There was significant positive correlation between microalbuminuria and fibronectin or HbA1c in groups IIb and IIIb. On the other hand there was a significant positive correlation between microalbuminuria and HbA1c in the same groups.
It can be concluded that the measurement of fibronectin one of the most efficient plasma protein markers of diabetic nephropathy reflecting vascular endothelial damage, but the measurement of microalbuminurea is still the hallmark for the diagnosis of incipient diabetic nephropathy. Early intervention at this stage may retard the progression towards ESRD.