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Abstract
The present study was done at Nephrology Unit of Pediatrics, and Biochemistry Departments, faculty of medicine, Zagazig University. from January , 2006 to January, 2007.
The current study was designated to investigate the relationship between plasma VEGF, urinary VEGF, and urinary VEGF ratio with both proteinuria and steroid responsiveness in children with nephrotic syndrome.
The study included 32 nephrotic patients, mean age of patients was (6.3±2.99) years, ranging from (2-14) years, (62.5%) were male (20 cases), (37.5%) were female (12 cases). We included in our study eight age and sex matched apparently healthy children as a control. Patients were subdivided into four groups. Group (I) included seven newly diagnosed cases, which represented 21.9%. Group (II) included seven steroid resistant cases, which represented 21.9%. Group (III) included eight steroid relapse cases, which represented 25%. Group (IV) included ten steroid responsive cases in remission, which represented 31.2%. Children in the study were subjected to; Recording body weight, Thorough history taking, laying stress on symptoms of nephrotic syndrome and its complications, detailed information about drug therapy particularly response to steroids. Clinical examination was done to confirm the diagnosis and to detect signs of remission or relapses, measurement of arterial blood pressure and looking for edema. Laboratory investigations were done to verify the diagnosis and the disease state: Complete blood picture, Complete urine analysis, Quantitative estimation of urinary protein by measuring urinary protein and urinary creatinine in a random urine sample, Serum cholesterol and serum creatinine, Serum protein and. Other laboratory investigations performed to monitor Circulating plasma vascular endothelial growth factor (VEGF), Urinary vascular endothelial growth factor (VEGF), Ratio of urinary vascular endothelial growth factor (VEGF) (U VGEF / U Creatinine) was calculated.
The median value of urinary protein / urinary creatinine ratio for cases was (1.965), and (0.045) for controls.