الفهرس Only 14 pages are availabe for public view
 |  | from | 147 |  |  |
| | | from | 147 | | |
Abstract
Abstract:
Bacterial sepsis due to bacterial contamination of blood components especially platelets components is potentially serious complication of transfusion.
These risks are 50 to 250 fold higher than the risk of transfusion related infection per unit associated with HIV, HCV, HBV and HTLV.
Objectives:
The aim of the present study is to review the clinical background and risks of bacterial contamination of blood components as well as addresses the strategies and regulatory approaches to decrease the transfusion associated morbidity and mortality risk of contaminated cellular blood products through:
Improving donor skin disinfection.
Removal of first aliquot of donor blood.
Pre- transfusion detection of bacteria.
Reducing recipient exposure.
Pathogen inactivation.
Conclusion:
The possible sources of bacterial contamination of blood components include introduction of bacterial through the phlebotomy site, asymptomatic donor bactremia, defects in plastic storage bags, prolonged storage and contamination during handling and processing of components.
Recent studies of platelets have suggested a bacterial contamination of about 1 per 300 units. Dealing effectively with this problem will involve continued and enhanced education of phlebotomy, technical, nursing, and medical staff with regard to sources of contamination and the importance of the problem.
Using approved products and procedures, blood collection centers can implement practices that may decrease bacterial contamination, including better skin disinfection, collection of blood with a diversion pouch set, testing for bacteria, and, potentially, the use of safe and effective pathogen reduction technologies if and when available.
Promising technologies for bacterial detection appear to be close at hand and offer significant potential to screen out contaminated units. A wide variety of measures have been proposed in order to reduce the frequency of transfusion-associated septic reactions and many of these measures are being actively investigated, and in some countries being instituted.
Thus, the potential reduction in the risk of transfusion-associated septic reactions is a realistic possibility in the foreseeable future.