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Abstract
One hundred and sixty albino rats were divided into eight groups as
follow:
Group A:
This group contains 20 rats. The rats were injected with diclofenac
sodium daily with a dose of 1.35 mg/rat/day. Samples of blood and
organs were collected from 5 rats every week for four weeks.
Group C-A:
This group contains 20 rats. The rats were injected with saline
daily as a control group. Samples of blood and organs were collected
from 5 rats every week for four weeks.
Group B:
This group contains 20 rats. The rats were locally applied with
diclofenac diethylammonium daily. Samples of blood and organs were
collected from 5 rats every week for four weeks.
Group C-B:
This group contains 20 rats. The rats were locally applied with
emulgel daily as a control group. Samples of blood and organs were
collected from 5 rats every week for four weeks.
Group C:
This group contains 20 rats. The rats were injected with diclofenac
sodium twice weekly with a dose of 1.35 mg/rat/dose. Samples of blood
and organs were collected from 5 rats every two weeks for eight weeks.
Group C-C:
This group contains 20 rats. The rats were injected with saline
twice weekly as a control group. Samples of blood and organs were
collected from 5 rats every two weeks for eight weeks.
Group D:
This group contains 20 rats. The rats were locally applied with
diclofenac diethylammonium twice weekly. Samples of blood and organs
were collected from 5 rats every two weeks for eight weeks.
Group C-D:
This group contains 20 rats. The rats were locally applied with
emulgel twice weekly as a control group. Samples of blood and organs
were collected from 5 rats every two weeks for eight weeks.
Blood samples were collected from the retro-orbital venous plexus
of rats for haemogram and serum biochemical analysis.
The haematological findings showed that there were decrease in
RBCs count, Hb concentration and PCV. The blood indices show
normocytic normochromic red blood corpuscles that indicate aplastic
anaemia due to the effect of the drugs on the bone marrow and it is
supported by the presence of megakaryocytes in the spleen as a mark for
extramedullary haematopieosis. There were decrease in number ofWBCs
and also there were increase in the number of lymphocytes and
monocytes that mean agranulocytosis.
The clinicopathological results showed hepalocellular damage
manifested by increase in AST, ALT , total, direct and indirect bilirubin
” .