الفهرس 
Patients and methodsOnly 14 pages are availabe for public view
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Abstract
Study limitations
A long term prospective study would be required to determine whether subjects
with abnormal endothelium-dependent vasodilatation are at increased risk of
developing clinically evident atherosclerotic disease in later life.
Most investigators have found that endothelial dysfunction is a diffuse
disorder that may affect the brachial, femoral, and coronary circulation even in
asymptomatic subjects at risk of vascular disease . This is consistent with
damaging effects of risk factors such as hypercholesterolemia ,diabetes mellitus
and systemic hypertension.
However, one report has suggested that endothelial dysfunction at least in
I
the coronary circulation may occur in patchy distribuation .If this was true in
other systemic arteries, it might influence the ability of this technique to detect
early vascular dysfunction. Furthermore, in this study we defined the cuttoff
point for endothelial dysfunction retrospectively by looking at the best test
results,we need next step ,a prosp~ctive study to reevalute this cuttoff point for
endothelial dysfunction at FMD%:S 4.5%.
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