الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Aim of the work
To determine whether bronchial asthma exacerbation in children associated with increased levels of serum sICAM-1 and sL-selection and to investigate the effect of the severity of exacerbation on these levels.
Conclusions and recommendations
From our study we can conclude that, asthma tends to run in families and there are sex differences in asthma morbidity with males more affected than females.
ICAM-1 and L-selection play a role in the inflammatory process in asthma. The serum levels of sICAM-1 and sL-selection were significantly higher in asthmatic children than healthy, also sICAM-1 and sL-selection levels showed significant variation according to the severity of asthma.
This finding suggests that serum sICAM-1 and sL-selection are a promising serological marker of the severity of inflammation in bronchial asthma in children. It wouldn’t only facilitate staging of inflammation but also allow the monitoring of therapy and intervention.
It is possible that concurrent inhibition of both molecules will provide even more impressive results in the control of airway inflammation and airway hyperresponsivness in asthma.
Thus, ICAM-1 and L-selection represent potential targets for novel asthma therapies.