الفهرس 
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Abstract
Summary and Conclusion
In order to investigate the role of CD4 CD25 regulatory T-cells in ITP pediatric patients and correlate their levels with the course and progression of the disease, this study was conducted on 45 children including 15 as controls and 30 cases with idiopathic thrombocytopenic purpura; ten cases of them were in the acute phase (Group I), ten were in the remission phase (Group II) and ten were in the chronic phase
(Group III).
Studied cases were subjected to the following investigations: Complete blood picture, erythrocyte sedimentation rate, coomb’s test and flowcytometric analysis of CD4 CD25 levels.
The present study revealed that:
- There was a highly significant decrease in the platelet count in patients of the acute group when compared to remission, chronic and control groups.
- There was a highly significant decrease in CD4 count in patients of the acute group when compared to remission, chronic and control groups.
- Also, there was a highly significant decrease in CD25 count in patients of the acute group when compared to patients of the remission, chronic and control groups.
- Moreover, there was a positive correlation between CD4 CD25 count and platelet count in all groups, this correlation was significant in acute group and insignificant in remission and chronic groups.
As a conclusion, the results suggest that decreased number of CD4 CD25 T-cells might be one of the mechanisms that cause immune regulation dysfunction in ITP. Furthermore, our results confirm that the count of CD4 CD25 T-cells is considered to be related to the severity of ITP as those cells significantly decreased in active phase of the disease and increased in the patients at the complete remission phase. Therefore, count of CD4 CD25 T-cells might be a helpful diagnostic predictor of onset and improvement of ITP in children. Finally, we suggest that these cells may have therapeutic implications that need further clarification.