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Abstract Aim of the work To evaluate the effects of rectal midazolam in comparison with rectal clonidine for premedication in pediatric surgery, as regard to the level of sedation, anxiolysis, hemodynamic stability, postoperative analgesia and side effects in a double-blinded randomized study. Conclusion We conclude that, rectal midazolam (300ug/kg) is superior to rectal clonidine (5ug/kg) as a pre anesthetic medication in children, because it produced more rapid and effective pre-operative sedation with better response to parent separation and mask application and obvious hemodynamic stability. As regard the post operative outcomes, clonidine seemed to have early postoperative analgesia, more prolonged postoperative sedation, less postoperative sevofluraine induced confusion, less incidence of shivering, nausea and vomiting. Recommendations We recommend further studies using combinations of rectal clonidine and midazolam, to get the benefits of pre-operative sedation and anxiolysis of midazolam and preferable postoperative outcomes of clonidine. |