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Abstract
The purpose of this study was to gain insight into the role of C-erb B-2 as a growth factor receptor gene and vimentin as an intermediate filament protein in salivary gland neoplasms. An investigation of the expression of C-erb B-2 and vimentin on the histopathological alterations of salivary gland neoplasms was conducted. A total of 30 paraffin blocks of different benign and malignant salivary gland neoplasms were included.
Tissue specimens were routinely processed, sectioned at 5 µ deparaffinized serial sections were prepared and stained with monoclonal antibodies against C-erb B-2 and vimentin. Following the microscopic examination, the results were statistically analysed and compared, using image analyzer to determine the average area percentage, for significant correlation with the tumor cell behavior.
1. a noticeable difference was found in the expressions of c-erb B-2 and vimentin in neoplastic cells in benign salivary gland tumors compared to those of malignant salivary gland tumors.
2. overxpression of c-erb B-2 was statistically correlated with salivary gland neoplasms that had larger sizes compared to those of smaller sizes.
3. overexpression of c-erb B-2 was statistically correlated with malignant salivary gland neoplasms that had lym