الفهرس 
pationts and methodsOnly 14 pages are availabe for public view
 |  | from | 94 |  |  |
| | | from | 94 | | |
Abstract
This study was intended to throw light on the effect of tonsillectomy on cellular immunity in children with recurrent attacks of acute
follicular tonsillitis
Immunological functions of the tonsil and possible effects of their removal are still controversial. One reason for this is the lack of follow-up investigation after tonsillectomy.
As an introduction to this study a detailed review of literature has been done to clarify different anatomical and physiological aspects
of the tonsils.
In the present study, selected parameters of the cellular immune system (unprimed naive T-cell (CD45 RA+), helper- T-cell (CD4) and cytotoxic T- cell (CD8) of twenty children 4-12 years (mean 8.2 and SD 2.441) before, one week and two months following
tonsillectomy were compared to these of ten age- matched non tonsillectomized children (mean6.8 andSD2.530). CD45 is a tyrosine phosphatase expressed on lymphocytes and act as positive regulator that is required for antigen stimulation and proliferation of
and B cell.
In tonsillectomized children, the incidence of infection of the upper respiratory tract was not increased compared to the non-tonsillectomized control group.
There was a significant increase of CD4 percentage and CD45 RA+ percentage in cases before tonsillectomy when compared with control group. While one week following tonsillectomy, there was statistically significant decrease of lymphocytic sub-populations CD4%, CD4 absolute count. CD4/CD8 ratio and CD45 RA+(%) by comparing to non- tonsillectomized children. Tonsillectomized children two months following operation were normal in all the parameter of cellular immune responses when compare to non-
tonsillectomized children.
This finding shows that while tonsillectomy may lead to certain changes in the cellular immune system, these alterations are clinically insignificant and no increased frequency of immunomodulated diseases should be expected.