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Abstract
Summary and conclusion
The process of sclerosis and stiffening is the leading phenomenon of the arterial changes in uraemia at young age and is clinically more apparent and possibly more important than the process of atheroma formation. Although risk factors are most likely to act in concert, producing both atheroma and sclerosis, this also implies that the driving force in this process is composed of a variety of factors leading to arterial stiffening, including hypertension, calcification and a decreased activity of endothelial relaxing factors. In more general terms, sclerosis develops faster than atheroma in young patients without significant co-morbidity. (Deneke, et al., 2001).
The aim of this study is to detect new markers for diagnosis and follow up of atherosclerosis in children with chronic renal failure.
We tried to prove the presence of atherosclerosis in those patients by doing carotid Doppler ultrasound for detection of carotid intimal medial thickness , also we tried to find the relation between CIMT and traditional and non traditional risk factors in those patients as age , duration of disease , duration of dialysis ,urea level , calcium phosphorous product , serum Ferritin , lipid profile , Arginine , Homocysteine and CRP.
This study was carried out in the department of pediatrics and diagnostic radiology department and biochemistry department, faculty of medicine, Zagazig University. In the period from July 2004 tell March 2006.
It included a total number of 50 subjects. They were selected and divided into 3 groups:-
-Group A, Comprised 20 patients with ESRD under regular hemodialysis I.e. GFR less than 10 ml\m2\min. Their mean age of (11.7±4.85) year there were (11) female 55% and (9) male 45%.
-Group B, Comprised 20 patients with chronic renal failure under regular conservative non dialysis management.I.e. GFR between 30 - 10 ml\m2\min. Their mean age (11± 3.37) year .There were (11) female and (9) male.