الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
Aim of the work
This work aims to evaluate the clinical utility of the newer version of anti-CCP (anti-CCP2) in patients with RA relative to patients with a diversity of rheumatic diseases. We intend to study the relationship between anti-CCP and disease activity parameters, functional disability, and radiological destruction in rheumatoid arthritis patients, as well as to examine the sensitivity and specificity of anti-CCP in those patients.
Conclusion
1- Anti-CCP is a useful serological test for establishing the diagnosis of rheumatoid arthritis and is associated with disease severity, radiological damage and disability.
2- There is modest but significant agreement between RF and anti-CCP, however anti-CCP is more sensitive and more specific than RF in the diagnosis of RA, with better positive and negative predictive values.
3- The combination of testing for both RF and anti-CCP is more useful than testing for either alone, since if either is present, sensitivity is increased, while if both are present, specificity is greatly enhanced.
4- Anti-CCP also helps to diagnose other inflammatory and non-inflammatory rheumatic diseases by reducing the rate of false positive results in comparison with RF.