الفهرس 
acknowledmentOnly 14 pages are availabe for public view
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Abstract
Three poorly water—soluble drugs salicylamide, enobarbitone and sulfathiazole wcro used to examine thc effect of compression pressure on the dissolution of m.pressed disks prepared from each drug with different ig content and particle size. At first, the dissolu— ion of 10% w/v drug suspensions a compared to the isso1ution of granules (10% drug content) to determine he effect of granulation on drug release. Granules of ach drug were prepared with three levels of drug content, 0, 30 and 50% using lactose as diluent. These granules are compressed at three compression pressures 7500, 2,5D0, 20,000 psi using Carver press. Dissolution rates the granules and compressed disks were performed sing the USP dissolution apparatus. cperimenta1 results ndicate that increasing the drug content decreased the issolution rate of granules and compressed disk. The sso1ution rate of compressed disk of fine and coarse ryatals varied with increasing the compressional force or each drug studied. The dissolution data were plainod on the basis of bonding and cleavage during apresion.