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Abstract In recent yeirs much attention has bQen foou. the problem of drug availability. ho drug milability is usually deterinined by the rate o’ 3.acae fran the physioal eyen commonr rQfarrod to the dosage foru. o obeotives of the present work were to inc ie dissolution rate of nalidixic acid which v osen as a model watorinso1uble drugs. Thio was oieved by using different teohniciues in order to eooize the most powerful of these teohniq.uos for thanoement of disoluti0n rate of NAI and conseque— tly its absorption and bioavailability. he drug formulated, via these teohnique, in different ab1t and suppository formulae to investigate the et preparation haring the acceptable eleao rate d, in turn, of øgooi bioava.ilability. his wi - aried out by testing those preparations in—vivo. |