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Abstract
The goal of the present study was to investigate the effect of sulfated polysaccharide extract of 3 categories of marine algae: red, green and brown. The species used in this study was Acanthophora spicifera, Ulva lactuca, Cystoseira trinode. Lipitor in atorvastatin drug is also used in treatment of hypercholesterolemic adult albino rats.
Our results showed the determination of total carbohydrate content in algae species. Sulfated polysaccharide extracted from marine algae using boiling water and IR spectra were recorded for these extracts.
Hypercholesterolemia was induced by addition of cholesterol powder and bile salt to the standard diet in percentage of 1% and 0.25% respectively to rats for about 15 days.
The present study revealed the effect of Acanthophora spicefira extract (200 mg/kg body weight), Ulva lactuca extract (175 mg/kg body weight), Cystoseira trinode extract (200 mg/kg body weight) and atorvastatin (0.09 mg/kg body weight) after 30 days of treatment on changes in body weight and liver weight, serum lipid profiles, cardiovascular risk factors (Atherogenic index, CK, and LDH), serum hepatic enzymes (ALT, AST and ALP), serum kidney functions (uric acid, urea, creatinine and urea/creatinine ratio) and oxidative stress in liver (TBAR, hepatic Catalase enzyme and glutathione) in hypercholesterolemic rats.