الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Aim of the work
This work aims to study the diagnostic and prognostic value of some autoantibodies; anti-CCP, and biochemical markers; HA and COMP, hs-CRP in OA patients and their relation to disease progression.
Conclusions
We can conclude that:
♦ The measurements of serum HA and COMP may be of diagnostic and prognostic value in differentiating patients with joint destruction and in determining disease progression.
♦ A single biochemical marker has definitive diagnostic value and the combination with other biochemical markers as well as with clinical and radiographic data would most likely help to improve the clinical assessment of patients affected with this common disorder.
♦ Serum HA and anti-CCP were the most specific markers with the highest positive predictive value.
♦ There was evidence of autoimmunity with OA and it was associated with presence of synovitis but not related to the degree of joint destruction.
♦ Clinical indices, NRSP and WOMAC are poorly related to the joint destruction or laboratory markers.
♦ Using the compartmental evaluation of Thomas score with biochemical markers is better than K-L grading system especially with short durations of follow up.