الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
The effect of sme frmulation factors on the dissoluticn
r!’te of the active inreiients from compressed tablets was irvesti3te. Sne adsrbents namely talc, magnesium stearate an aerosil were use1 as representatives of lubricants. The investigatiDn deals with the effect vf the type of tablet lubricant in the usual c)noefltratjon usec or the dissolition of some soiuble drugs as quinine hyc1roch1orie, antazoline hydro— clorj’e ani caffeine citrate. 3everai tc’es of tablets were reparej by wet granulation, each batc1- containe’ different
°°flCentrat ion of the lubricant under investigation. The in—vitro l’elease characteristic3 of these tablets were perforieJ in 0.l! h/rcchjoric acid.
The result cbtained in’icate’. that although aerosil is a
Ydrophilic lubricant, yet increasing its cncentratiori caused
Ietardation of the rate of :Iissolution of antazoline hydrochlorici feine citrate anl quinine hyroch1oride tablets. This retar-.
in the rate of dissolution was attributed to adsorption
these drugs on the surface of aerosil.